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No. 6 Oklahoma boasts an undefeated 4-0 record ahead of Week 5, but could face a significant challenge this weekend. On Saturday, the Sooners will play their first true road game of 2021 against 3-1 Kansas State in a Big 12 matchup. Oklahoma has had two close games in a row and hopes to avoid dropping a third straight conference matchup against the Wildcats.

Kickoff at Bill Snyder Family Stadium is set for 3:30 p.m. ET. Caesars Sportsbook lists the Sooners as 12.5-point favorites in the latest Oklahoma vs. Kansas State odds. The over-under for total points scored is 53. Before making any Kansas State vs. Oklahoma picks, be sure to see the college football predictions and betting advice from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, it enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Oklahoma vs. Kansas State and it just revealed its CFB picks and predictions. You can visit SportsLine now to see the model's CFB Week 5 picks. Now, here are the college football odds and betting lines for Kansas State vs. Oklahoma:

  • Oklahoma vs. Kansas State spread: Oklahoma -12.5
  • Oklahoma vs. Kansas State over-under: 53
  • Oklahoma vs. Kansas State money line: Sooners -475, Wildcats +360
  • OKLA: The Sooners are 5-0 straight up in their last five games
  • KST: The total has gone over in five straight Wildcats home games against the Sooners

Why Oklahoma can cover

The Sooners' lone double-digit win this year came against Western Carolina in a 76-0 rout. However, they still have the talent to dominate the Wildcats. Since the end of last season, Oklahoma has been on a roll. It can end its losing streak against Kansas State with a bounce-back performance. The Sooners have covered in five of their last 10 games against the Wildcats. They've also been highly successful against the spread in their previous eight games.

Oklahoma is 7-1 against the spread in its last eight games overall and as the favorite. While the home team in this matchup is 4-1 against the spread over the previous five meetings, the Sooners are a more complete team. Thanks to Spencer Rattler, they have a significant offensive advantage. He's thrown for 1,017 yards while completing 74.1 percent of his passes this year. 

Why Kansas State can cover

Kansas State is 3-1, and its only defeat came in a 31-20 loss against No. 19 Oklahoma State on the road last week. The Wildcats' pass defense has been rock solid in 2021 and could help them keep the score close. They've given up just four passing touchdowns ahead of Week 5, and Oklahoma has been dependent on Spencer Rattler's arm.

Rattler has thrown a single touchdown pass in three of his four appearances this year. Oklahoma won by less than a touchdown in each of those matchups. The young signal-caller has yet to play a road game in 2021, and that could give the home team the edge it needs. Kansas State has covered as a double-digit underdog against Oklahoma four times in a row.

How to make Kansas State vs. Oklahoma picks

SportsLine's model is leaning over on the point total, projecting 56 combined points. It also has generated an against-the-spread pick that cashes in over 60 percent of simulations. You can get the pick over at SportsLine.

So who wins Oklahoma vs. Kansas State? And which side of the spread hits over 60 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that is up almost $3,300 on its top-rated college football spread picks, and find out.